We've all heard the horror stories of life in middle management. In Japan, the ill appears to be especially acute. So many Japanese workers die from simply being overworked that there's a name for it: karoshi. Wikipedia says, "The major medical causes of karōshi deaths are heart attack and stroke due to stress." From March 2006 to March 2007, 303 people were claimed to have died of it with 147 of those cases acknowledged as accurate by the government.
Thirty-year-old Kenichi Uchino worked 60 hours a week for five months for Toyota in Japan, and then worked 70 hours a week for a month -- and then he died.