I don't know that this would be useful as a workstation "desktop", but as file organization of graphical and semi-graphical data goes, these guys seem to have hit a new plateau of utility. They've got a long video of an (apparently working) UI for the 3D representation of files as physical objects to factiltate cleaning up like one would their desk (if they ever cleaned their desk). There's some things it's not going to handle, but... Try not to think about the hand-jewelry too much. Some people are just born that way.
I strongly recommend you watch the YouTube video all the way through (especially you Mac users).
BumpTop Desktop Interface useful?